![]() controlled release, programmed release, sustained release, prolonged release, timed release, extended release etc. There are several terms used interchangeably viz. Ĭontrolled release dosage forms cover a wide range of prolonged action formulations which provide continuous release of drug at the specific site for a predetermined time at a predetermined rate. The oral controlled release formulations have been developed for those therapeutic agents that are easily absorbed from the G.I.T, having a shorter half life, eliminated quickly from the blood circulation, narrow absorption window as these will release the drug slowly into the G.I.T. Physicochemical characteristics of drug and delivery mode under study.Pharmacodynamics and pharmacokinetic profile of drug. ![]() The first approach has many disadvantages, however second approach can be used widely.Īn ideal controlled drug delivery system is that which delivers the drug at a specific rate locally or systemically for a specified period of time with minimum fluctuation in plasma drug concentration, reduced toxicity and maximum efficiency. Effective and safer use of existing drugs through concepts and techniques of controlled and targeted drug delivery systems.Development of new, better and safer drugs with long half-life and large therapeutic indices.Īpproaches to overcome these limitations: Multiple drug therapy enhances the risk of toxicity as well as overall cost of treatment.Poor patient compliance chances of dose missing.Limitations of conventional oral dosage form: But conventional dosage form offers few limitations which could be resolved by modifying the existing dosage form. Among the various routes of drug delivery oral route is most widely used route of drug delivery. ![]() Drugs are never administered in their pure form but are converted in a suitable formulation so that its onset and intensity of action as well as total duration of action can be checked. Drugs are administered with a main aim of curing patient ailments. The term “Drug Delivery” covers a very extensive range of techniques used to deliver therapeutic agents into the human body. The present article concentrates on oral sustained release tablets with a special emphasis on matrix tablet.Ĭonventional tablet, Sustained release, Controlled release, Polymer, Matrix tablet. Thus, sustained release matrix tablet can offer better patient compliance and could be quite helpful in treatment of chronic diseases. The rate of drug release from the matrix is primarily goverened by rate & extent of water penetration, swelling of polymer, dissolution & diffusion of drug. Matrix tablets can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers. Hence the problem like poor patient compliance, multiple dosing, see-saw fluctuations can be easily minimized. There are various formulation strategies for sustained release tablets among which matrix tablet serves as an important tool. Sustained and controlled drug delivery system helps in maintaince of constant plasma drug concentration and retards the release rate of drug therby extending the duration of action. Among the various routes of drug delivery oral route is most preferred route.
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